Research Archive

This research paper, authored by Yassin Bassem, investigates the revolutionary impact of continuous glucose monitoring (CGM) systems on diabetes management. CGMs represent a technological leap from traditional self-monitoring blood glucose (SMBG) devices, offering real-time glucose monitoring and predictive insights. The study emphasizes the global scalability of CGM technologies, focusing on accessibility in low- and middle-income countries (LMICs). By leveraging advancements in wearable technology and artificial intelligence, CGMs have the potential to revolutionize diabetes care and enhance global health equity.

Diabetes is a chronic condition affecting millions globally. This research explores the transformative role of Continuous Glucose Monitoring (CGM) systems as superior alternatives to Self-Monitoring Blood Glucose (SMBG) devices. SMBG relies on intermittent fingerstick testing, which limits its ability to provide real-time insights or track glucose trends effectively. CGM systems overcome these limitations by continuously measuring glucose levels in the interstitial fluid through subcutaneous sensors, transmitting real-time data to smartphones or receivers.

The paper evaluates key challenges, such as high costs and technological barriers, especially in LMICs. It highlights the integration of CGMs with machine learning for predictive analytics and explores how global collaborations can drive accessibility. The study argues for targeted subsidies, cost reduction strategies, and public-private partnerships to scale CGM adoption globally, improving glycemic control and reducing diabetes-related complications.

The research revealed that CGMs significantly outperformed SMBGs in critical metrics:

• Improved Glycemic Control: Studies demonstrated a 0.25%–0.31% reduction in HbA1c levels with CGMs compared to SMBGs, highlighting their efficacy in managing diabetes.
• Enhanced Detection: CGMs detected 9% more cases of nocturnal hypoglycemia, a critical benefit for preventing severe complications.
• Cost-Effectiveness: Although CGMs have higher upfront costs, they offer long-term savings by reducing hospitalizations and improving quality-adjusted life years (QALYs).

Case studies in LMICs showed that locally manufactured and subsidized CGMs improved adoption rates by 15%. The integration of hybrid closed-loop systems demonstrated additional benefits, automating insulin delivery and enhancing patient outcomes.

You can find the full paper here: [LINK]

This research paper, authored by Yassin Bassem and Jana Ahmed, explores the multifaceted challenges of traumatic brain injury (TBI). Underpinned by extensive studies and clinical data, it delves into the epidemiology, pathophysiology, and global impact of TBIs, emphasizing their prevalence in young adults and high-risk populations such as athletes and military personnel. The mentorship of leading neuroscientists guided this research, addressing critical gaps in diagnostic tools and treatment pathways. A primary focus is on the molecular mechanisms underlying TBI, including diffuse axonal injury and neuroinflammatory responses, contributing to advancements in both acute care and long-term rehabilitation strategies.

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, primarily resulting from external mechanical forces like rapid acceleration, deceleration, or blast waves. This research examines the biophysical and neuropathological mechanisms of TBIs, including the impact of rotational and linear forces on brain structures. It evaluates innovative diagnostic methods such as diffusion tensor imaging (DTI) and biomarkers like neurofilament light (NF-L) to enhance early detection.

Key areas of exploration include the role of axonal injury in cognitive and behavioral deficits, the progression of chronic traumatic encephalopathy (CTE), and the long-term implications of repeated mild TBIs. By integrating case studies and clinical trials, this paper highlights cutting-edge treatment approaches, from surgical interventions for hematomas to non-invasive techniques like EEG-based neurofeedback.

The study's ultimate goal is to bridge the gap between acute management and comprehensive rehabilitation, paving the way for personalized medicine and improving quality of life for TBI survivors.

The findings underscore the pivotal role of advanced imaging techniques and biomarkers in diagnosing and managing TBIs. For instance, diffusion tensor imaging (DTI) successfully identified axonal injuries that conventional MRI missed, providing critical insights into the extent of neural damage. Biomarkers like NF-L and tau proteins demonstrated their potential in monitoring injury severity and predicting recovery trajectories.

Case studies revealed that integrating surgical and non-surgical interventions significantly improved patient outcomes. Innovations in neurofeedback and metabolic imaging showcased their efficacy in addressing cognitive deficits and enhancing neural plasticity. Moreover, the research highlighted the socioeconomic impact of TBIs, advocating for accessible diagnostic tools and rehabilitation programs tailored to diverse populations.

You can find it here: [LINK]

Donor Connect is a groundbreaking initiative designed to tackle the critical shortage of blood donations. This platform leverages modern technology to connect blood donors with recipients and hospitals, facilitating the process of blood donation and collection. It integrates GPS, gamification, and user-friendly interfaces to create a seamless and engaging experience for users. The project emphasizes increasing awareness about the importance of blood donation and simplifying the logistics involved.

The main challenges addressed by Donor Connect include the reluctance of individuals to donate blood due to misinformation or lack of awareness, the logistical difficulties in matching donors with recipients, and the time-sensitive nature of blood transfusions. Furthermore, the platform seeks to overcome infrastructural constraints in underdeveloped areas by providing a digital solution that minimizes manual intervention.

Donor Connect has the potential to revolutionize the blood donation landscape. By creating a centralized and accessible system, it improves donor engagement, increases the availability of blood supplies, and reduces the risk of critical shortages. The integration of gamification incentivizes regular donations, while real-time updates ensure efficient management of blood inventory. Ultimately, the platform saves lives by addressing a long-standing healthcare challenge.